Jin 2007.

Methods	This was a randomised, controlled, parallel clinical trial
Participants	1. Setting: The trial recruited participants from an outpatient department of dermatology in a Chinese medicine hospital in Shenzhen, China 2. Age: from 10 to 52 years of age 3. Sex (men/women): 40/22 4. Number of participants randomised: 62 5. T/C: 32/30
Interventions	I. Treatment group 1. Jianpi Zhiyang granules 1.1 Ingredients and dosage Huangqi (Radix astragali) Baizhu (Rhizoma atractylodis macrocephalae) Danggui (Radix angelicae sinensis) Heshouwu (Radix polygoni) Shengdihuang (Radix rehmanniae) Baishao (Radix paeoniae alba) Chuangxiong (Rhizoma chuanxiong) Fangfeng(Radix saposhnikovia) Jingjie(Herba schizonepetae) Baijili (Fructus tribuli terrestris) Gouteng (Ramulus uncariae cum uncis) Gancao(Radix glycyrrhizae) Did not provide dosage of the ingredients 1.2 Administration 10 g 3 times daily, oral ingestion 1.3 Duration of treatment 4 weeks 1.4 Follow up Did not state II. Control group 2. Loratadine tablet 2.1 Ingredients and dosage Loratadine 10 mg/tablet 2.2 Administration 1 tablet daily, oral ingestion 2.3 Duration of treatment 4 weeks 2.4 Follow up Did not state
Outcomes	1. SCORAD score 2. Severity of itching score (measured by patient‐rated VAS, scale 0 to 10) 3. Serum IgE level and eosinophil count All assessments were conducted at baseline and at the end of the 4‐week treatment period
Notes	1. The trial did not report adverse events 2. The treatment intervention was the same as that orally ingested in the Yang 2007 study
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	This was not stated
Allocation concealment (selection bias)	Unclear risk	This was not stated
Blinding of participants and personnel (performance bias) All outcomes	High risk	This was not stated Comment: The appearance and administration of the 2 interventions were different, so it is unlikely that a blinding method was used
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	This was not stated
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Quote: "Those who did not completed the trial were excluded" Comment: The numbers of participants randomised and analysed were equivalent. It seems that there were no withdrawals/dropouts in this study
Selective reporting (reporting bias)	Unclear risk	There was insufficient information
Other potential sources of bias (use of published validated scoring system )	Low risk	The trial used SCORAD