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. 2013 Sep 10;2013(9):CD008642. doi: 10.1002/14651858.CD008642.pub2

Shi 2012.

Methods This was a randomised, controlled, parallel clinical trial
Participants 1. Setting: The trial recruited participants from a women's and children's hospital in Guangzhou, China
2. Age: from 5 to 25 years of age
3. Sex (men/women): 45/66
4. Number of participants randomised: 110
5. T/C: 54/56
Interventions I. Treatment group
1. Chinese herbal decoction
1.1 Ingredients and dosage
  • Huangqi (Radix astragali) 15 g

  • Baizhu (Rhizoma atractylodis macrocephalae) 10 g

  • Yiyiren (Semen coicis) 10 g

  • Beishashen (Radix glehniae) 15 g

  • Fangfeng(Radix saposhnikovia) 15 g

  • Fuling (Poria) 10 g

  • Gancao(Radix glycyrrhizae) 6 g


1.2 Administration
  • 1 pack of herbs cooked with water and the decoction drank twice daily


1.3 Duration of treatment
  • 3 weeks


1.4 Follow up
  • Did not state


II. Control group
2. Cetirizine tablet
2.1 Ingredients and dosage
  • Desloratadine 10 mg


2.2 Administration
  • Once daily oral ingestion


2.3 Duration of treatment
  • 3 weeks


2.4 Follow up
  • Did not state

Outcomes 1. Percentage of reduction of total SASSAD score
2. Effectiveness rate
3. QoL
4. Serum CD3+CD4+T cells and CD3+CD8+T cells, immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), and IgE
Assessments were conducted at baseline and at the end of the 3‐week treatment period, respectively
Notes 1. Effectiveness rate = ((pre‐treatment score of SASSAD ‐ post‐treatment score of SASSAD)/pre‐treatment score of SASSAD) * 100%
2. We contacted the corresponding trial investigator for further information (such as why there was discrepancy in the number of participants and sum of the genders, and randomisation method, diagnostic criteria, report of adverse events, and data on QoL). We received no reply