Table 1.
Name | Endpoint | License type | Prediction models available at |
---|---|---|---|
ADMET predictor | Elevation of DILI biomarkers (ALP, AST, LDH) |
Commercial software (GUI* program) | |
Derek Nexus | Severity of DILI | Commercial software (GUI* program) | |
VEGA | Hepatotoxicity (Positive/Unknown/Negative) | Freeware (GUI program) | https://www.vegahub.eu/portfolio-item/vega-qsar/ |
Liver NOAEL and LOAEL | |||
Hepatic steatosis MIEs (PXR/PPARα/PPARγ/NRF2) | |||
ProTox–II | Hepatotoxicity classification (Positive/Negative) | Freeware (Web program) | https://tox-new.charite.de/protox_II/ |
Nrf2/ARE classification | |||
Mitochondrial membrane potential classification | |||
ToxSTAR | Binary classification of DILI indications (Cholestasis, Cirrhosis, Hepatitis, and Steatosis) | Freeware (Web program) | https://toxstar.kitox.re.kr/ |
admetSAR | Hepatotoxicity classification | Freeware (Web program) | http://lmmd.ecust.edu.cn/admetsar2 |
BSEP inhibition | |||
Mitochondrial toxicity |
GUI: Graphical User Interface