Table 2.

Selected list of liver AOPs from AOP wiki (accessed on 21 Mar 2023)

AOP ID	Title	Molecular initiating events (MIEs)
27	Cholestatic liver injury induced by inhibition of the bile salt export pump (ABCB11)	Bile salt export pump inhibition (ABCB11)
34	LXR activation leading to hepatic steatosis	LXR activation
		PPAR promoter demethylation
36	Peroxisomal Fatty Acid Beta-Oxidation inhibition leading to steatosis	PPAR-α, β, γ activation decrease
57	AhR activation leading to hepatic steatosis	AhR activation
58	CAR suppression leading to hepatic steatosis	CAR suppression
		PPAR-α inhibition
		LXR activation
		PPAR promoter demethylation
59	HNF4 α suppression leading to hepatic steatosis	HNF4 α suppression
60	PXR activation leading to hepatic steatosis	PXR/SXR activation
61	NFE2L2/FXR activation leading to hepatic steatosis	NRF2 activation
		NR1H4 activation
62	AKT2 activation leading to hepatic steatosis	Systemic inflammation leading to hepatic steatosis
220	CYP2E1 activation leading to liver cancer	Activation of CYP2E1
232	NFE2/Nrf2 repression to steatosis	NFE2/Nrf2 repression
273	Mitochondrial complex inhibition leading to liver injury	Inhibition of any mitochondrial complexes (I, II, III, IV, or V)
278	IKK complex inhibition leading to liver injury	IKK complex inhibition
317	Glucocorticoid receptor activation leading to hepatic steatosis	Glucocorticoid receptor activation