Table 4.

Selected list of toxicogenomics database (accessed on 6th July)

Abbreviations	Descriptions	Available at
BioPlanet	Integration of human pathways with the healthy and disease state annotations and targets.	https://tripod.nih.gov/bioplanet/
CHemDIS	Chemical-disease inference system is deployed with interfaces for enrichment analysis for functions, pathways and diseases to identify chemicals with potential risks.	http://cwtung.kmu.edu.tw/chemdis
CTD	Comparative Toxicogenomics Database provides manually-curated chemical-gene/protein interactions, chemical-disease and gene-disease relationships curated manually.	https://ctdbase.org/
DisGeNET	DisGeNET is a platform to integrate information on human disease-associated genes and variants.	https://www.disgenet.org/
DrugMatrix	Toxicogenomic reference resources. Data is reported through ToxFX. It is no longer supported by National Toxicology Program; however, source code of DrugMatrix and ToxFX will be available in Github	https://ntp.niehs.nih.gov/data/drugmatrix
LINCS	The Library of Integrated Network-Based Cellular Signatures contains a variety of data based on the data level concept in the Cancer Genome Atlas.	https://lincsproject.org/
MSigDB	Molecular Signatures Database provides annotated gene sets for *GSEA software	https://www.gsea-msigdb.org/gsea/msigdb
Reactome	Reactome is a biological pathway database manually curated and peer-reviewed.	https://reactome.org/
TG-GATEs	Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System is developed from the Japanese Toxicogenomics Project Consortium from 170 compounds.	https://www.toxicodb.ca/datasets/1

^*GSEA: Gene Set Enrichment Analysis