Table 2.
Diagnostic and therapeutic data of interest comparing patients with sepsis and MIS-C
| Total (n = 116) | Sepsis (n = 87) | MIS-C (n = 29) | p value | |
|---|---|---|---|---|
| Laboratory data (at admission) | ||||
| Hemogram parameters | ||||
| Leukocyte count (/mm3); median (IQR) | 12,500 (6200–18,200) | 12,800 (6900–21,725) | 9600 (5600–13,350) | 0.01 |
| Lymphocyte count (/mm3); median (IQR) | 1200 (600–2500) | 1600 (725–2754) | 800 (400–1250) | 0.02 |
| Neutrophil count (/mm3); median (IQR) | 7200 (3600–13,700) | 7300 (3075–14,075) | 6700 (4000–11,700) | 0.97 |
| Platelet count (× 103/µL); median (IQR) | 194 (113–305) | 225 (157–351) | 119 (100–178) | 0.001 |
| Coagulation parameters | ||||
| Prothrombin time (%); median (IQR) | 60.2 (47.5–72.5) | 58.7 (45.5–71.3) | 64.7 (51.7–80.25) | 0.20 |
| Partial thromboplastin time (seconds); median (IQR) | 30.2 (26.5–34.8) | 30.3 (27.4–36) | 28.5 (24.9–33.1) | 0.06 |
| Fibrinogen (g/L); median (IQR) | 5.1 (4.45–6.45) | 4.6 (4.05–5.85) | 6.4 (4.9–7.2) | 0.001 |
| D-dimer (mg/L); median (IQR) | ** | ** | 6.25 (3.29–8.14) | ** |
| Biochemical parameters | ||||
| Glucose (mg/dL); median (IQR) | 101 (84–131) | 98.5 (80.5–121) | 137 (122–178) | 0.02 |
| Creatinine (mg/dL); median (IQR) | 0.58 (0.44–0.75) | 0.53 (0.39–0.75) | 0.63 (0.56–0.75) | 0.35 |
| Urea (mg/dL); median (IQR) | 26.3 (19–42.9) | 26 (17–43.8) | 26.9 (21.9–42.5) | 0.63 |
| ALT (UI/L); median (IQR) | 22 (15–48) | 20.5 (12–42.5) | 40 (20–51.5) | 0.81 |
| AST (UI/L); median (IQR) | 33 (24–52) | 30 (18–52.7) | 39 (28.5–52.5) | 0.57 |
| Total bilirubin (mg/dL); median (IQR) | 11.6 (9.1–19.7) | 12.7 (9.5–19.9) | 9.8 (7.3–19.2) | 0.83 |
| Conjugated bilirubin (mg/dL); median (IQR) | 7.1 (5.3–9.6) | 7.3 (4.1–8.2) | 7.1 (5.4–11.2) | 0.56 |
| Protein (g/L); median (IQR) | 56 (51–64) | 55 (46–64.5) | 58 (53–62.5) | 0.83 |
| Albumin (g/L); median (IQR) | 26 (22–30.3) | 26.5 (23–31.8) | 25.5 (20.8–29) | 0.35 |
| ESR (mm); median (IQR) | 13 (4.8–30) | 7 (3.3–26.5) | 18 (6.5–31.8) | 0.19 |
| C-reactive protein (mg/L); median (IQR) | 136.8 (51.2–244) | 87 (39.3–215.3) | 230.9 (156.2–295.3) | 0.41 |
| Procalcitonin (ng/mL); median (IQR) | 11.7 (2–43.8) | 17.5 (1.7–49.8) | 8.4 (2.4–16.9) | 0.01 |
| Lactate (mmol/L); median (IQR) | 2.15 (1.48–3.2) | 1.9 (1.3–3.08) | 2.75 (1.78–3.33) | 0.38 |
| Adrenomedullin (nmol/L); median (IQR) | 1.53 (0.94–2.82) | 1.47 (0.86–3.45) | 1.72 (1.26–2.40) | 0.01 |
| Ferritin (µg/L); median (IQR) | 1008.3 (366.2–1748.3) | 1096.9 (360.8–3829.8) | 944.6 (369.9–1479.1) | 0.001 |
| IL-6 (pg/mL); median (IQR) | ** | ** | 158 (61–552) | ** |
| Ionogram parameters | ||||
| Sodium (mmol/L); median (IQR) | 137 (135–140) | 137 (135–141) | 135 (132–138) | 0.003 |
| Potassium (mmol/L); median (IQR) | 3.8 (3.4–4) | 3.8 (3.4–4.1) | 3.7 (3.5–4) | 0.70 |
| Chlorine (mmol/L); median (IQR) | 106 (102–111) | 107 (103–111) | 102 (99–108) | 0.08 |
| Calcium (mmol/L); median (IQR) | 1.18 (1.09–1.24) | 1.16 (1.07–1.23) | 1.19 (1.16–1.27) | 0.01 |
| Cardiovascular affection (diagnostic and therapeutic) | ||||
| Troponin (ng/mL); median (IQR) | 0.068 (0.010–0.830) | 0.010 (0.000–0.770) | 0.082 (0.014–0.906) | 0.44 |
| NT-ProBNP (ng/L); median (IQR) | 6839 (4114–21,501) | 13,169 (3089–23,250) | 6839 (4208–19,167) | 0.71 |
| Creatine kinase (UI/L); median (IQR) | 70.5 (35.5–282.8) | 115 (40.5–346) | 59 (33–94) | 0.30 |
| Cardiac dysfunction (LVEF < 50%); n (%) | 25/116 (22%) | 11/87 (13%) | 14/29 (48%) | <0.001 |
| Requirement of inotropic support; n (%) | 72/116 (62%) | 53/87 (61%) | 19/29 (66%) | 0.65 |
| VIS; median (IQR) | 12 (8–25) | 10 (8.5–26) | 15 (8–25) | 0.55 |
All the data indicated in bold are values of p < 0.05 that are considered statistically significant
ALT alanine aminotransferase, AST aspartate aminotransferase, ESR erythrocyte sedimentation rate, IL-6 interleukin-6, NT-ProBNP N-terminal pro-brain natriuretic peptide, LVEF left ventricular ejection fraction, VIS vasoactive inotropic score
**Missing values