TABLE 2.

Association of four dementia-related polygenic risk scores (as a continuous variable, per SD) with risk of incident dementia.

Dementia-related polygenic risk score	Model 1		Model 2		Model 3
	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
PRS-83SNP	1.35 (1.23–1.47)	2.85E-11	1.37 (1.26–1.50)	3.12E-12	1.35 (1.23–1.47)	5.33E-11
PRS-SBayesR	1.39 (1.27–1.51)	6.48E-13	1.37 (1.26–1.50)	3.07E-12	1.37 (1.25–1.50)	9.51E-12
PRS-CS	1.43 (1.31–1.57)	3.56E-15	1.42 (1.30–1.56)	1.43E-14	1.42 (1.30–1.56)	1.67E-14
PRS-23SNP	1.11 (1.02–1.21)	0.02	1.12 (1.03–1.23)	0.01	1.12 (1.02–1.22)	0.02

Note: Cox PH regression models were used to estimate the hazard ratio (HR) of the PRS per standard deviation, with 95% confidence intervals (CIs). Model 1 was adjusted for age at recruitment, sex, and first 20 genetic PCs. Model 2 was additionally adjusted for the number of APOE ε4 and APOE ε2 alleles. Model 3 was further adjusted for baseline smoking status, alcohol drinking status, BMI, living status, years of education, CES-D-10, diabetes status, systolic blood pressure, diastolic blood pressure, dyslipidemia, and dementia family history