TABLE 3.
Association of four dementia-related polygenic risk scores (as a continuous variable, per SD) with risk of incident dementia for subgroups according to alcohol drinking status and the number of APOE-ε4.
| Subgroup analysis | PRS-83SNP |
PRS-SBayesR |
PRS-CS |
PRS-23SNP |
|||||
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| Alcohol drinking | Current | 1.28 (1.16–1.42) | 2.21E-06 | 1.29 (1.16–1.43) | 2.09E-06 | 1.35 (1.22–1.50) | 2.27E-08 | 1.06 (0.96–1.18) | 0.25 |
| Former | 1.26 (0.85–1.88) | 0.25 | 1.08 (0.73–1.62) | 0.69 | 1.24 (0.81–1.89) | 0.33 | 1.07 (0.72–1.58) | 0.74 | |
| Never | 1.74 (1.40–2.16) | 6.58E-07 | 1.95 (1.56–2.43) | 2.84E-09 | 1.84 (1.49–2.28) | 1.43E-08 | 1.41 (1.14–1.74) | 1.75E-03 | |
| Number of APOE-ε4 | 0 | 1.40 (1.25–1.58) | 1.53E-08 | 1.52 (1.34–1.71) | 1.69E-11 | 1.59 (1.40–1.79) | 1.12E-13 | 1.08 (0.96–1.21) | 0.22 |
| 1 | 1.37 (1.18–1.59) | 3.13E-05 | 1.27 (1.10–1.48) | 1.44E-03 | 1.33 (1.15–1.54) | 1.64E-04 | 1.25 (1.07–1.45) | 4.31E-03 | |
| 2 | 0.59 (0.35–1.02) | 0.06 | 0.67 (0.41–1.09) | 0.11 | 0.53 (0.30–0.92) | 0.02 | 0.82 (0.50–1.34) | 0.43 | |
Note: Cox PH regression models were used to estimate the hazard ratio (HR) of the PRS per standard deviation with 95% confidence intervals (CI), adjusted for age at recruitment, sex, first 20 genetic PCs, the number of APOE-ε4 and APOE-ε2 alleles, baseline smoking status, alcohol drinking status, BMI, living status, years of education, CES-D-10, diabetes status, systolic blood pressure, diastolic blood pressure, dyslipidemia, and dementia family history (Model 3).