TABLE 4.

AUC estimates at a mean of 6.5 years of follow-up and comparisons for predictions of dementia risk.

Model	AUC (95% CI)	p-value
Baseline	71.0% (68.7%–73.3%)
Baseline + APOE	74.7% (72.6%–76.8%)	3.27E-06 (vs Baseline)
Baseline + APOE + PRS-83SNP	75.7% (73.7%–77.8%)	0.007 (vs Baseline + APOE)
Baseline + APOE + PRS-SBayesR	76.0% (74.0%–78.0%)	0.004 (vs Baseline + APOE)
Baseline + APOE + PRS-CS	76.1% (74.1%–78.2%)	0.003 (vs Baseline + APOE)
Baseline + APOE + PRS-23SNP	74.7% (72.6%–76.8%)	0.95 (vs Baseline + APOE)
Baseline + APOE + PRS-83SNP + PRS-SBayesR	76.2% (74.2%–78.2%)	0.06 (vs Baseline + APOE + PRS-83SNP)
		0.22 (vs Baseline + APOE + PRS-SBayesR)
Baseline + APOE + PRS-83SNP + PRS-CS	76.5% (74.5%–78.5%)	0.03 (vs Baseline + APOE + PRS-83SNP)
		0.13 (vs Baseline + APOE + PRS-CS)
Baseline + APOE + PRS-SBayesR + PRS-CS	76.2% (74.2%–78.2%)	0.40 (vs Baseline + APOE + PRS-SBayesR) 0.61 (vs Baseline + APOE + PRS-CS)

Note: The baseline model includes the predictors in Model 3, excluding APOE genotype variables (the number of ε4 and ε2 alleles) and PRS, that is, age at recruitment, sex, first 20 genetic PCs, smoking status, alcohol drinking status, BMI, living status, years of education, CES-D-10, diabetes status, systolic blood pressure, diastolic blood pressure, dyslipidemia, and dementia family history. p-value was obtained through the DeLong test by comparing AUCs from two nested models.