Table 1.
Total Inclusions and Patient Demographics of the Children on Dolutegravir in the CHAPAS4 Pharmacokinetic Substudy
| Characteristic | All Children (N = 39) |
TAF/FTC Backbone (n = 19) |
ABC/3TC Backbone (n = 12) |
ZDV/3TC Backbone (n = 8) |
|---|---|---|---|---|
| Weight band, No. of children | ||||
| 14–19.9 kg | 9 | 4 | 3 | 2 |
| 20–24.9 kg | 10 | 5 | 2 | 3 |
| 25–34.9 kg | 8 | 4 | 3 | 1 |
| ≥35 kg | 12 | 6 | 4 | 2 |
| Sex, No. (%) | ||||
| Male | 21 (54) | 8 (42) | 10 (83) | 3 (47) |
| Female | 18 (46) | 11 (58) | 2 (17) | 5 (63) |
| Age, y, median (IQR; range) | 10.8 (7.8–13.3; 5.5–15.5) | 11.1 (7.8–13.2; 5.5–14.2) | 11.3 (7.9–14.3; 6.3–15.5) | 9.5 (6.9–13.9; 6.2–15.2) |
| Weight, kg, median (IQR; range) | 27.0 (20.0–35.8; 15.9–53.0) | 27.0 (20.0–35.2; 15.9–53.0) | 29.3 (19.6–37.5; 16.7–47.2) | 22.7 (19.3–34.6; 17.5–51.7) |
Abbreviations: 3TC, lamivudine; ABC, abacavir; FTC, emtricitabine; IQR, interquartile range; TAF, tenofovir alafenamide fumarate; ZDV, zidovudine.