Scheme 1: PTH(1–34) bound to PTH1R shown in a nanodisc.

The C terminus of PTH(1–34) (orange) interacts with the extracellular domain of the receptor, while the N terminus of the peptide hormone interacts with the juxtamembrane domain. The receptor is surround by a lipid bilayer (grey), which is held together with the alpha helical membrane scaffold protein MSP1E3D1 (purple).