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. Author manuscript; available in PMC: 2023 Nov 11.
Published in final edited form as: ACS Chem Biol. 2018 Jul 11;13(8):2347–2358. doi: 10.1021/acschembio.8b00568

Scheme 3: Extracellular domain of PTH1R has a high density of negatively charged residues.

Scheme 3:

Snake plot of PTH1R shows negatively charged residues in red, which are clustered towards the extracellular side of the receptor. Two regions of PTH1R not conserved in family B GPCRs are boxed: the 50-residue flexible loop contains 8 negatively charged residues and the 16-residue extracellular loop 1 contains 6 negatively charged residues.