Table 2.

Association of CHEK2 variants with breast cancer risk

CHEK2 statusa	Cases (n = 506)		Controls (n = 459)		ORb	95% CI
	n	%	n	%
1100del C
Noncarrier	499	98.8	456	99.6	1.0	Reference
Carrier	6	1.2	2	0.4	2.9	(0.6–14.6)
R145W
Noncarrier	505	99.8	459	100.0	1.0	Reference
Carrier	1	0.2	0	-	-	-
I175T
Noncarrier	504	99.6	455	99.1	1.0	Reference
Carrier	2	0.4	4	0.9	0.5	(0.1–2.6)

^aAll carriers are heterozygous. ^bAdjusted for age at reference and reference year. CI, confidence interval; OR, odds ratio.