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. Author manuscript; available in PMC: 2023 Nov 12.
Published in final edited form as: Lancet Child Adolesc Health. 2020 Feb 28;4(4):281–289. doi: 10.1016/S2352-4642(20)30023-7

Table 2.

Parameter estimates for the bone length models for girls with Progeria, in comparison to those of normal girls. L is the length at birth, H is the eventual bone length, (β1, β2, β3) determine the growth rate, and δ is the difference in eventual bone lengths based on childhood (Hchild) and adolescent (Hadol) measurement methods. Ratios refer to Progeria/normal ratios for adolescent asymptotes and Progeria/normal ratios for half-lives (the time taken to grow from L to half the distance between L and H). For each bone, all parameters (L, H, δ and (β1, β2, β3) taken as a group) were significant (p<0.001).

L (cm) H+δ
Hchild (cm)
H Hadol (cm) ratio for asymptote β1 β2 β3 half-life ratio for half-life
Humerus Normal 6.6 30.4 33.1 - 0.18 −0.018 0.0013 5.7 -
Progeria 6.6 18.5 20.1 0.61 0.25 −0.024 0.0013 3.8 0.67
Radius Normal 5.3 22.8 24.8 - 0.16 −0.016 0.0012 6.2 -
Progeria 5.3 12.8 13.7 0.55 0.40 −0.049 0.0030 2.3 0.38
Ulna Normal 6.0 24.6 26.3 - 0.18 −0.018 0.0013 5.9 -
Progeria 6.0 14.6 15.2 0.58 0.35 −0.048 0.0031 2.9 0.49
Tibia Normal 6.3 35.1 40.2 - 0.18 −0.017 0.0015 5.4 -
Progeria 6.3 21.6 23.9 0.60 0.30 −0.034 0.0023 3.3 0.61
Fibula Normal 6.0 34.9 38.9 - 0.18 −0.016 0.0013 5.3 -
Progeria 6.0 19.7 22.2 0.57 0.34 −0.039 0.0025 2.7 0.51