Table 2.

Parameter estimates for the bone length models for girls with Progeria, in comparison to those of normal girls. $L$ is the length at birth, $H$ is the eventual bone length, (${\beta }_1$, ${\beta }_2$, ${\beta }_3$) determine the growth rate, and $\delta$ is the difference in eventual bone lengths based on childhood ($H_{child}$) and adolescent ($H_{adol}$) measurement methods. Ratios refer to Progeria/normal ratios for adolescent asymptotes and Progeria/normal ratios for half-lives (the time taken to grow from $L$ to half the distance between $L$ and $H$). For each bone, all parameters ($L$, $H$, $\delta$ and (${\beta }_1$, ${\beta }_2$, ${\beta }_3$) taken as a group) were significant (p<0.001).

		$L$ (cm)	$H+\delta$ $H_{child}$ (cm)	H $H_{adol}$ (cm)	ratio for asymptote	${\beta }_1$	${\beta }_2$	${\beta }_3$	half-life	ratio for half-life
Humerus	Normal	6.6	30.4	33.1	-	0.18	−0.018	0.0013	5.7	-
	Progeria	6.6	18.5	20.1	0.61	0.25	−0.024	0.0013	3.8	0.67
Radius	Normal	5.3	22.8	24.8	-	0.16	−0.016	0.0012	6.2	-
	Progeria	5.3	12.8	13.7	0.55	0.40	−0.049	0.0030	2.3	0.38
Ulna	Normal	6.0	24.6	26.3	-	0.18	−0.018	0.0013	5.9	-
	Progeria	6.0	14.6	15.2	0.58	0.35	−0.048	0.0031	2.9	0.49
Tibia	Normal	6.3	35.1	40.2	-	0.18	−0.017	0.0015	5.4	-
	Progeria	6.3	21.6	23.9	0.60	0.30	−0.034	0.0023	3.3	0.61
Fibula	Normal	6.0	34.9	38.9	-	0.18	−0.016	0.0013	5.3	-
	Progeria	6.0	19.7	22.2	0.57	0.34	−0.039	0.0025	2.7	0.51