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. Author manuscript; available in PMC: 2023 Nov 12.
Published in final edited form as: Sci Signal. 2023 Aug 8;16(797):eadf2173. doi: 10.1126/scisignal.adf2173

Fig. 2. 3D mutational landscape depiction of residues affecting Gαq and β-arrestin responses.

Fig. 2.

(A to C) Residue positions that significantly affect Gαq coupling upon mutation as assessed by EC50 in green (A), Emax in red (B) and RA (C) (inset colors). (D to F) Residue positions that significantly affect β-arrestin coupling upon mutation as assessed by EC50 in green (D), Emax in red (E) and RA (F) (inset colors). Residue positions are overlaid on the AT1R structure (PDB ID: 6OS0) by displaying the Cɑ atom of each residue. (G) Bar plots of the RA values for the displayed residues above in (C) and (F). Raw values are provided in data file S3.