Table 2.

Distribution of participating nuclear families according to mother's breast cancer status, mother's and father's carrier status of the CYP17 and CYP19 variant alleles, and number of affected and unaffected daughters

	Number of nuclear families according to mother's breast cancer status and genotype							Number of nuclear families according to father's genotype
Number of daughters affected/unaffected	Affected			Unaffected			Total				Total
	Carrier	Non-carrier	Unknown	Carrier	Non-carrier	Unknown		Carrier	Non-carrier	Unknown
CYP17
1/0	3	0	19	17	12	29	80	12	2	66	80
1/1	5	2	38	16	6	85	152	19	4	129	152
1/2	0	0	2	4	0	14	20	4	2	14	20
1/3	0	0	1	2	0	0	3	0	0	3	3
2/0	2	0	3	1	1	9	16	0	0	16	16
2/1	0	0	0	0	0	2	2	0	0	2	2
2+/2+	0	0	1	2	0	1	4	1	0	3	4
Total	10	2	64	42	19	140	277	36	8	233	277
CYP19 > = 10 repeats
1/0	4	0	17	14	13	29	77	7	4	66	77
1/1	5	1	40	12	9	88	155	10	6	139	155
1/2	1	0	1	5	1	14	22	5	2	15	22
1/3	1	0	0	1	0	0	2	1	0	1	2
2/0	1	0	4	1	1	9	16	1	0	15	16
2/1	0	0	0	0	0	2	2	0	0	2	2
2+/2+	0	0	1	0	1	2	4	0	0	4	4
Total	12	1	63	33	25	144	278	24	12	242	278
CYP19 = 11 repeats
1/0	4	0	17	11	16	29	77	6	5	66	77
1/1	5	1	40	11	10	88	155	9	7	139	155
1/2	1	0	1	6	1	13	22	5	3	14	22
1/3	1	0	0	1	0	0	2	1	0	1	2
2/0	1	0	4	1	1	9	16	1	0	15	16
2/1	0	0	0	0	0	2	2	0	0	2	2
2+/2+	0	0	1	0	1	2	4	0	0	4	4
Total	12	1	63	30	29	143	278	22	15	241	278