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Inhibition of spontaneous tumor formation by vaccination with virus-like replicon particles (VRP)-neu. Groups of MMTV-c-neu transgenic mice (n = 10 per group) were vaccinated three times (▼) at 2-week intervals with 106 IU VRP-neu (▲) or 106 IU VRP-hemagglutinin (HA) (■). The mice vaccinated with VRP-HA were killed when moribund, and the mice vaccinated with VRP-neu were killed at 240 days.
