Fig. 6.

Schematic illustration of the mechanisms of modulating the tumor microenvironment to achieve deep penetration. (A) Targeting collagen in the microenvironment by albumin conjugates to enhance deep penetration. (B) Degradation of the ECM to facilitate transport of drugs encapsulated in polymers. (C) Molecules involved in remodeling the tumor microenvironment to promote drug penetration. Note: ECM, extracellular matrix; HAase, hyaluronidase; TME, tumor microenvironment; IFP, high interstitial fluid pressure; CAF, cancer-associated fibroblast; TGF-$\beta$, transforming growth factor $\beta$; MMPs, matrix metalloproteinases; HIFs, hypoxic-inducing factors; CTGF, connective tissue growth factor; VEGF, vascular endothelial growth factor. (Fig. 6 was created with BioRender.com.).