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. 2023 Oct 26;32:445–472. doi: 10.1016/j.bioactmat.2023.10.017

Fig. 7.

Fig. 7

Modulation of the tumor microenvironment to achieve deep penetration. (A) Targeting collagen in the tumor microenvironment via DOX-CBD-SA to enable drug accumulation and deep penetration: (i) Schematic representation of the mechanism of action of DOX-CBD-SA. (ii) Structure of the conjugate. iii) Deep penetration achieved by this conjugate. (B) Diagram for the mechanism of peptide hybrid liposomes (MRPL) responsive to MMP-2 in the tumor microenvironment to achieve deep penetration: Illustration of down-regulation of the ECM in pancreatic tumors via MMP-2-responsive MRPL. (C) Schematic for the mechanism of action of MMPs. MMPs play a critical role in remodeling of the extracellular matrix and facilitating deep penetration of therapeutic agents in the tumor microenvironment. Note: CBD, collagen-binding domain; SA, serum albumin; DOX-CBD-SA, Doxorubicin was conjugated to the CBD-SA; MMPs, matrix metalloproteinases; MRPL, a matrix metalloproteinase-2 responsive peptide-hybrid liposome. (Fig. 7A was reprinted with permission from Ref. [102]. Copyright 2019 AAAS. Fig. 7B was adapted with permission from Ref. [62]. Copyright 2017 American Chemical Society. Fig. 7B and C were created with BioRender.com.).