Table 2.
Summary of MEVO studies currently enrolling patients.
| Study name | DISTAL (NCT05029414) |
ESCAPE-MeVO (NCT05151172) |
DISCOUNT (NCT05030142) |
DISTALS (NCT05152524) |
REVISAR (NCT04479020) |
||
|---|---|---|---|---|---|---|---|
| Primary outcome | mRS* | mRS* | mRS 0–2 at 90 days | Successful reperfusion | Successful reperfusion | ||
| Time window | ≤ 24 h | ≤ 12 h | ≤ 6 h | ≤ 24 h | N.A | ||
| Disability cut-off | NIHSS≥ 4/disabling deficit | NIHSS≥ 5/NIHSS 3–5° | NIHSS≥ 5 | NIHSS 4–24/NIHSS 2–24∆ | N.A | ||
| Upper age limit | No | No | No | 85 | N.A | ||
| Occlusion location | ACA | A1 | Yes | No | Yes | Yes | Yes |
| A2 | Yes | Yes | Yes | Yes | Yes | ||
| A3 | Yes | Yes | Yes | Yes | Yes | ||
| PCA | P1 | Yes | No | Yes | Yes | Yes | |
| P2 | Yes | Yes | Yes | Yes | Yes | ||
| P3 | Yes | Yes | Yes | Yes | Yes | ||
| MCA | M2 | Non/co-dominant M2 | Yes | Distal M2¥ | Non/co-dominant M2 | After bifurcation | |
| M3 | Yes | Yes | Yes | Yes | Yes | ||
| M4 | Yes | No | No | No | N.A | ||
DISTAL: Endovascular therapy plus best medical treatment vs best medical treatment alone for medium vessel occlusion stroke – a pragmatic, international,multicenter randomized trial; ESCAPE-MeVO: Endovascular treatment to improve outcomes for medium vessel occlusions; DISCOUNT: Evaluation of mechanical thrombectomy in acute ischemic stroke related to a distal arterial occlusion; DISTALS: Distal ischemic stroke treatment with adjustable low-profile stentretriever; REVISAR: Recanalization of distal cerebral vessels in acute stroke using ApeRio; ¥ defined as above the mid-height of the insula; ° with disabling deficit; * not specified; ∆ with isolated aphasia or hemianopsia; N.A: not applicable; mRS: modified Rankin Scale; ACA: anterior cerebral artery; PCA: posterior cerebral artery; MCA: middle cerebral artery.