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Inhibition of PA-NLRP3 inflammasome axis-induced inflammation and ECM degradation by Xn. A. mRNA expression of NLRP3, ASC, and caspase 1 detected using qPCR. Protein expression of NLRP3, ASC, caspase-1, pro-caspase-1, IL-1β, and pro-IL-1β detected using western blotting (B) and quantification results (C). *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001.
