Table 5.
Haplotype 2 and risk of breast cancer by family history of breast cancer in the Nurses' Health Study
| Family history | Case (frequency)a | Control (frequency)a | OR (95% CI) | ORb (95% CI) |
| None | ||||
| Other/other | 668 (51) | 995 (58) | 1.00 (reference) | 1.00 (reference) |
| Hap2/other | 351 (27) | 456 (27) | 1.16 (0.97–1.38) | 1.13 (0.95–1.35) |
| Hap2/Hap2 | 39 (2.9) | 43(2.5) | 1.36 (0.86–2.15) | 1.34 (0.84–2.15) |
| Present | ||||
| Other/other | 165 (12) | 145 (8) | 1.69 (1.33–2.17) | 1.78 (1.38–2.29) |
| Hap2/other | 77 (5.8) | 75 (4.4) | 1.51 (1.07–2.12) | 1.60 (1.13–2.27) |
| Hap2/Hap2 | 14 (1.1) | 3 (0.2) | 10.06 (2.25–45.0) | 10.83 (2.39–49.2) |
CI, confidence interval; Hap2, haplotype 2; OR, odds ratio.
aSamples lacking genotype information at all four SNPs were removed from haplotype analysis.
bLogistic regression controlling for age, age of menopause, post-menopausal hormone use, age at first birth, parity, and history of benign breast disease. P interaction = 0.05.