PRESERVE study setting and organizational structure. PRESERVE includes 16 institutions from 5 PCORnet networks: (1) Children’s Hospital of Philadelphia (Coordinating Center), Cincinnati Children’s Hospital Medical Center, Children’s Hospital Colorado, Indiana University/Riley Hospital for Children, Lurie Children’s Hospital, Nationwide Children’s Hospital, Nemours Children’s Health, Seattle Children’s Hospital, and Stanford Children’s Health (PEDSnet); (2) University of North Carolina (STAR); (3) Medical College of Wisconsin/Children’s Wisconsin and University of Iowa Stead Family Children’s Hospital (GPC); (4) University of Michigan/C.S. Mott Children’s Hospital and Johns Hopkins Children’s Center (PaTH); and (5) University of Florida/Shands Children’s Hospital and University of Miami/Holtz Children’s Hospital (OneFlorida+). PRESERVE also includes linkages with the US Renal Data System (USRDS) and Chronic Kidney Disease in Children (CKiD) study.