Table 4.
Fold changes and relative abundance for deregulated isoforms in brain versus melanoma
| Gene | Isoform | Fold changes | Relative abundance | |||||
|---|---|---|---|---|---|---|---|---|
| Brain/Melanoma | Melanoma | Brain | ||||||
| LF+SF (RE1) | LF (RE2) | SF (RJ) | Reference | Experimental | ||||
| % LF | % SF | % LF | % SF | |||||
| PPIB | Wild type (SF) | 0.38 | 1.17 | 0.36 | 2.5 | 97.5 | 7.6 | 92.4 |
| Intron 4 retention (LF) | ||||||||
| APPa | Wild type + APP [-8] (LF) | 1.39 | 0.94 | 3.81 | 84.3 | 15.7 | 57.0 | 43.0 |
| Exon7- 8 skipping (APP [-7/8] (SF) | ||||||||
| MGC8721 | Wild type (LF) | 3.41 | 3.18 | 1.71 | NA | NA | NA | NA |
| Exon 2 skipping (SF) | ||||||||
Significant deregulations are reported in bold. RE2 values correspond to the mean of fold changes calculated with each LF-specific probes (Ex2, J1-2 and J2-3). NA, not applicable (see in text the limitations for the relative abundance determination).
aSee description of APP in Figure 4C.