Figure 1.

The sensitization protocol was conducted for 28 days. On days 1 and 14, BALB/c mice received intraperitoneal (i.p.) injection of OVA solution. On days 21, 23, 25, and 27, the animals were exposed to 1% OVA aerosol for 30 minutes. The control group received intraperitoneal saline solution and 0.9% saline solution aerosol. PPE instillation was performed intratracheally on day 21. Treatment groups were given neutralizing anti-IL-17 antibody intraperitoneally on days 22, 23, 25, and 27. On day 28, respiratory system mechanics measurements and bronchoalveolar lavage collection were performed.