. 2023 Oct 27;14:1271342. doi: 10.3389/fimmu.2023.1271342

Table 1.

Absolute values of remodeling markers in the alveolar septa.

PULMONARY REMODELING MARKERS	SAL	OVA	OVAANTI-IL-17	PPE	PPEANTI-IL-17	ACO	ACOANTI-IL-17
MMP-9 (Positive Cells/10⁴µm²)	8.11 ± 1.72	20.89 ± 1.48*	11.41 ± 1.03&	11.65 ± 1.61*	7.20 ± 0.68&	15.79 ± 1.82*	7.93 ± 1.13&
MMP-12 (Positive Cells/10⁴µm²)	13.41 ± 2.98	23.94 ± 0.94*	18.99 ± 0.92	21.13 ± 1.80*	15.13 ± 1.85&	23.72 ± 1.64*	14.61 ± 1.86&
TIMP-1 (Positive Cells/10⁴µm²)	0.17 ± 0.17	11.25 ± 3.56*	3.84 ± 1.82&	2.45 ± 1.39*	1.48 ± 0.80	10.08 ± 3.84*+	4.39 ± 1.96&
TGF-β (Positive Cells/10⁴µm²)	0.16 ± 0.10	5.93 ± 2.34*	0.89 ± 0.57&	9.57 ± 2.72*	0.50 ± 0.17&	12.35 ± 2.16*#	1.78 ± 0.93&
Total Collagen Fiber (%)	0.01 ± 0.08	1.32 ± 3.97*	0.55 ± 2.25	0.20 ± 1.52	0.19 ± 1.49	1.23 ± 3.05*	0.02 ± 0.1
Type I Collagen Fiber (%)	2.07 ± 0.43	9.98 ± 1.99*	4.1 ± 0.50&	9.08 ± 1.25*	2.60 ± 0.46&	14.02 ± 1.51*	3.53 ± 0.57&
Type III Collagen Fiber (%)	0.35 ± 0.05	9.42 ± 1.54*	1.49 ± 0.35&	3.93 ± 0.87*	0.12 ± 0.04&	8.28 ± 1.23*	2.54 ± 0.40&
Type V Collagen Fiber (%)	1.84 ± 0.38	7.65 ± 1.44*	3.77 ± 0.68&	3.47 ± 0.81	2.07 ± 0.38&	9.01 ± 0.63*+	1.77 ± 0.26&

Remodeling markers for MMP-9, MMP-12, TIMP-1 and TGF-ß are expressed as positive cells/10⁴µm². Total collagen fibers and subtypes I, III and V are presented as volume fraction expressed as percentages of area (%). Mean ± standard error of remodeling markers assessment for all experimental groups. Values are presented as absolutes. *p < 0.05, compared to the SAL group; + p < 0.05 comparado ao grupo PPE; # p < 0.05 comparado ao grupo OVA; &p < 0.05, compared to the OVA, PPE, and ACO groups.