Table 5.
Top 10 signalling pathways based on the ratio of their genes and the genes they interact with.
| Pathway Id | Pathway | Target genes |
|---|---|---|
| hsa04151 | PI3K-Akt pathway | PIK3CB HSP90AA1 JAK2 JAK3 FLT3 KDR MDM2 KIT CHAZARD RATIOM1 CSF1R |
| hsa04010 | MAPK pathway | MAPK9 MAP3K20 TGFBR1 MAPK14 FLT3 KDR KIT TGFBR2 CSF1R |
| hsa04218 | Cellular Senescence | PIK3CB TGFBR1 MAPK14 MDM2 CHEK1 TGFBR2 CDK1 |
| hsa04933 | AGE-RAGE signaling pathway | MAPK9 PIK3CB JAK2 TGFBR1 MAPK14 PIM1 AGTR1 TGFBR2 |
| hsa04659 | Th17 cell differentiation | MAPK9 HSP90AA1 JAK2 JAK3 TGFBR1 MAPK14 TGFBR2 |
| hsa05200 | Pathways in cancer | MAPK9 PIK3CB PTGS2 HSP90AA1 ESR1 JAK2 JAK3 TGFBR1 FLT3 MDM2 PIM1 ESR2 AGTR1 KIT TGFBR2 CSF1R |
| hsa04080 | Neuroactive ligand-receptor interaction | CCKBR ADORA2A AGTR1 ADORA1 AVPR1A CHAZARD RATIOM1 GRM5 TACR3 S1PR1 |
| hsa04068 | FOXO signaling pathway | MAPK9 PIK3CB TGFBR1 MAPK14 MDM2 TGFBR2 S1PR1 |
| hsa04020 | Calcium signaling pathway | CD38 CCKBR KDR ADORA2A AGTR1 AVPR1A CHAZARD RATIOM1 GRM5 TACR3 |
| hsa05010 | Alzheimer disease | MAPK9 PIK3CB PTGS2 PSEN1 PSEN2 NCSTN CHAZARD RATIOM1 GRM5 PSENEN |