Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Nov 13;223(1):e202203005. doi: 10.1083/jcb.202203005

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 Wu et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure S5. — Related to Figs. 7 and 8. Combined CDK1/2 and EGFR inhibitors have a synergetic anticancer effect in vivo. (A and B) The date of gene expression from the CCLE database or proteomics from https://depmap.org. The cell lines were classified according to the site of the disease. The correlation between ERK1 or ERK2 with USP37 was analyzed in isotype cell line respectively. P < 0.05 was considered statistically significant. Pearson correlation coefficient was used to represent the size of the correlation. (C) Tissue derived from five colon cancer patients was examined for ERK1/2 and USP37 protein levels by Western blot. The highest ERK1/2 colon cancer tissue among these five colon cancer tissues was employed to construct xenograft (PDX) models derived from patients. (D) ERK1/2, p-ERK1/2, and USP37 protein levels from the colon cancer PDX xenografts (Fig. 8 F) were examined by Western blot. Source data are available for this figure: SourceData FS5.