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. 2023 Oct 4;299(11):105319. doi: 10.1016/j.jbc.2023.105319

Figure 3.

Figure 3

Altered senescence and EGFR pathways in PrP KO cells as detected by bulk RNA sequencing.A, volcano plot showing changed transcripts between WT and PrP KO NSCs. B, gene ontology analyses showing the five most changed categories in biological process (red), cellular component (green), and molecular function (blue) for genes that are upregulated and downregulated in PrP KO NSCs. The number of genes changed in each category is indicated at the end of each bar. Pale blue coloring of the molecular function bars denotes that this category did not reach the threshold for statistical significance. C, heatmaps (Z-scores) of gene selections associated with senescence, apoptosis, cell cycle, and EGFR signaling broken down into pathways showing relative changes in PrP KO NSCs. ∗∗∗Padj < 0.001, ∗∗ Padj < 0.01, and ∗Padj < 0.05. EGFR, epidermal growth factor receptor; NSC, neural stem cell; PrP, prion protein.