Table 1.
Top ten gene ontology classes for genes changed in both PrP KO NSCs and EGF-WT NSCs as compared with the WT normal EGF control cells
| Genes upregulated (p < 0.01) | Genes downregulated (p < 0.01) |
|---|---|
| Regulation of epidermal growth factor receptor signaling pathway (GO:0042058) | Mitochondrial electron transport, ubiquinol to cytochrome c (GO:0006122) |
| Epidermal growth factor receptor signaling pathway (GO:0007173) | Negative regulation of Notch signaling pathway (GO:0045746) |
| Autophagosome maturation (GO:0097352) | Apoptotic mitochondrial changes (GO:0008637) |
| ERBB signaling pathway (GO:0038127) | Glycosphingolipid biosynthetic process (GO:0006688) |
| Regulation of ERBB signaling pathway (GO:1901184) | Mitochondrial ATP synthesis coupled electron transport (GO:0042775) |
| Lysosomal transport (GO:0007041) | ATP synthesis coupled electron transport (GO:0042773) |
| Protein targeting to vacuole (GO:0006623) | Protein localization to endoplasmic reticulum (GO:0070972) |
| Fatty acid beta-oxidation (GO:0006635) | Aerobic electron transport chain (GO:0019646) |
| Regulation of cell shape (GO:0008360) | Ribonucleoside diphosphate metabolic process (GO:0009185) |
| Negative regulation of protein-containing complex assembly (GO:0031333) | Purine ribonucleoside diphosphate metabolic process (GO:0009179) |
Italics denote categories associated with EGFR signaling, and bold indicates categories associated with energy production.