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. 2023 Oct 12;299(11):105344. doi: 10.1016/j.jbc.2023.105344

Figure 2.

Figure 2

OGT/O-GlcNAc regulates major hallmarks of tumor progression. OGT and O-GlcNAc are critical in regulating metabolic profile and significantly contribute to driving metabolic plasticity of cancer cells. OGT and O-GlcNAc are also involved in promoting cancer cell proliferation and survival, contributing to driving resistance to anti-cancer therapies. OGT and O-GlcNAc in many cancers are critical for metastasis by regulating invasion/migration and cancer stem-like cell properties. Some newly discovered mechanisms of cancer cell activity are listed. Created with BioRender.com.