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. 2023 Nov 13;21(11):e08353. doi: 10.2903/j.efsa.2023.8353

FIGURE 12.

FIGURE 12

Total folate intake and incident colorectal cancer, most adjusted RRs from PCs and NCCs. Intake values, age and duration correspond to the mean/median of each category; mandatory fort, yes/no: reflects policy status at baseline; (cc): incident colon cancer; (rc): incident rectal cancer; In Kato et al. the cases denote CRC morbidity; In Le Marchand et al., the values are for the CC genotype; For Lee et al. (2011), Zschäbitz et al. (2013) and Gibson et al. (2011), mandatory fortification was considered as of 1998. Set categories refers to: Lee et al. (2011), Q1 (ref): <250; Q2: 250– < 400; Q3: 400– < 600; Q4: 600– < 800; Q5: ≥800 μg total folate/day, Gibson et al. (2011), Q1 (ref): ≤199; Q2: 200– ≤ 299; Q3: 300– ≤ 399; Q4: 400– ≤ 499; Q5: 500– ≤ 599; Q6: 600– ≤ 699; Q7: 700– ≤ 799; Q8: 800– ≤ 899; Q9: ≥900 μg total folate/day. AT, Austria; DE, Germany; DK, Denmark; FI, Finland; NL, The Netherlands; US, United States; pc, prospective cohort; ncc, nested case–control study; Dur, duration; Mand fort, mandatory fortification, n per cat, number of participants per category; n event per cat, number of events per category; DFE, dietary folate equivalent.