. 2023 Nov 13;21(11):e08353. doi: 10.2903/j.efsa.2023.8353

TABLE 8.

Outcome of the systematic search on folate and cognitive impairment (sQ2b).

LoE	Endpoints	RCTs	PCs/NCCs
LoE1. Standalone (main)	Changes in functional measures of cognitive function	1	3 P/S folate: 2 RBC folate: 0 P/S UFA: 0 Dietary intake of FA/folate: 0
LoE1. Standalone (main)	Incidence of dementia or Alzheimer disease	0	1

LoE

Endpoints

RCTs

PCs/NCCs

LoE1. Standalone (main)

Changes in functional measures of cognitive function

P/S folate: 2

RBC folate: 0

P/S UFA: 0

Dietary intake of FA/folate: 0

LoE1. Standalone (main)

Incidence of dementia or Alzheimer disease

Abbreviations: FA, folic acid; LoE, line of evidence; NCC, nested case–control; P/S, plasma/serum; PC, prospective cohort; RBC, red blood cell; RCT, randomised controlled trial; UFA, unmetabolised folic acid.