Scheme 1.

Reagents and Conditions for the Synthesis of Designed BRD7 Inhibitors^a

^a(a) NaH, DMF (anhydrous), CH₃I at 0 °C warm to rt, 16 h; (b) Pd(dppf)Cl₂, Cs₂CO₃, DMF (anhydrous), reflux, 16 h; (c) Pd(dppf)Cl_2, Cs₂CO₃,, 1,4-dioxane (anhydrous), reflux, 48−72 h; (d) aryl aldehyde in THF at 0 °C, Grignard reagent added over 10 min, then quenched; (e) pyridinium dichromate, DCM.