Figure 5.
The Pcdh19E48X mutation affects lateral MOR28 coalescence in males at 7 weeks
(A–H) Projection of image stack obtained by light sheet microscopy (A, C, E, and G) and segmented to define projection patterns on the lateral surface (B, D, F, and H). Arrowheads indicate primary glomerular projection based on percent GFP expression.
(I) The number of lateral projections per half-bulb.
(J) The percent GFP present in the main projection is different between male mutants and controls.
(K) Histogram of distribution of GFP expression within each projection (greater than 3%) in the various genotypes. Scale bar: 100 μm. One way ANOVA (J) F(3,12) = 6.012, Dunnett’s test. ∗p < 0.05. n = 3 (M cntrl), 6 (M mut), 3 (F mut), and 4 (F het).