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Evaluation of BRD4 PROTACs 43–45 in MOLT4 cells. (A) Western blot analyses of BRD4, BRD3, BRD2, and actin protein levels in MOLT4 cells treated with pomalidomide (POM), PROTACs 43 or the CRBN-recruiting reference dBET57 or the VHL-recruiting reference MZ1 for 24 h at 0.1 μM. (B) Western blot analyses of the homologous series 43h, 44h, and 45h at three different concentrations after treatment of MOLT4 cells for 24 h.
