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(A) Chemical structures of reported dual inhibitors of HDAC6 and a second target protein.32−35 The Zn2+-binding core structure of the HDAC6-targeted subunit, a N-hydroxybenzamide, is highlighted in red. (B) Chemical structures of heterobifunctional ligands for Sirt2.19,37 The core structure of the Sirt2-targeted inhibitor, a SirReal, is highlighted in blue.
