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Dual Sirt2/HDAC6 inhibitors increase α-tubulin acetylation levels in PC-3M-luc prostate cancer cells. Cells were treated with 20 μM of Sirt2 inhibitor or DMSO (vehicle) for 5 h before imaging. Representative images (n = 4) show acetylation levels of α-tubulin in red and the DAPI-stained nuclei in blue. Scale bar represents 24 μm.
