. 2023 Oct 30;66(21):14787–14814. doi: 10.1021/acs.jmedchem.3c01385

Table 2. Dual Sirt2/HDAC6 Inhibitors Tested by Means of a Biochemical in Vitro Demyristoylation Assay.⁴⁷^a.

compd	Sirt2 (demyristoylation)
21	ni^b
22	ni^b
31	29 ± 1
32	1.7 ± 0.2
33	9.7 ± 1.3
44	34 ± 2
45	2.8 ± 0.6
46	13.2 ± 1.9
4	1.4 ± 0.3
5	2.5 ± 0.2^c
55	ni^b
56	ni^b
57	<15% @ 5 μM
SAHA	18% @ 10 μM

IC₅₀ values [μΜ, mean ± SD] or percentual inhibition at a given concentration of the dual Sirt2/HDAC6 inhibitors, as well as reference compounds for selective Sirt2 inhibition (4,5), HDAC6 inhibition (55–57), and SAHA as an nonselective inhibitor of Zn²⁺-dependent HDACs.

ni = no inhibition (inhibition <15% @ 20 μM).

Values for 5 taken from Vogelmann et al.⁴⁷

Table 2. Dual Sirt2/HDAC6 Inhibitors Tested by Means of a Biochemical in Vitro Demyristoylation Assay.47a.

Table 2. Dual Sirt2/HDAC6 Inhibitors Tested by Means of a Biochemical in Vitro Demyristoylation Assay.⁴⁷^a.