Table 2. PDE11A4 Inhibition^a.

cpd	amine	R1	R2	R3	% inhib @ 500 nM	IC50 (nM)
9a	diethyl	2-thiophenyl	CH3	H		580
9b	pyrrolidinyl	2-thiophenyl	CH3	H	0
9c	azetidinyl	2-thiophenyl	CH3	H	0
9d	morpholinyl	2-thiophenyl	CH3	H	0
9e	N-Me-piperazinyl	2-thiophenyl	CH3	H	0
11	diethyl	H	CH3	H	0
12	diethyl	CN	CH3	H	0
13	diethyl	pyrrolidinyl	CH3	H	0
14a	diethyl	2-thiazolyl	CH3	H		890
14b	diethyl	N-Me-5-pyrazolyl	CH3	H		53
14c	diethyl	N-Et-5-pyrazolyl	CH3	H		61
14d	diethyl	N-iPr-5-pyrazolyl	CH3	H	50
14e	diethyl	N-Me-3-pyrazolyl	CH3	H	19
14f	diethyl	N-Me-4-pyrazolyl	CH3	H	66
14g	diethyl	NH-5-pyrazolyl	CH3	H	21
14h	Piperidinyl	N-Me-5-pyrazolyl	CH3	H		4800
14i	t-Bu	N-Me-5-pyrazolyl	CH3	H	22
14j	Me-n-propyl	N-Me-5-pyrazolyl	CH3	H		630
14k	Me-Et	N-Me-5-pyrazolyl	CH3	H		500
15	diethyl	2-Me-3,4-oxadiazolyl	CH3	H	0
18a	diethyl	N-Et-5-pyrazolyl	CH3	2-F		62
18b	diethyl	N-Me-5-pyrazolyl	CH3	3-F	65
18c	diethyl	N-Me-5-pyrazolyl	CH3	4-F		91
18d	diethyl	N-Me-5-pyrazolyl	CH3	2-Cl		51
18e	diethyl	N-Me-5-pyrazolyl	CH3	4-Cl	51
20a	diethyl	N-Et-5-pyrazolyl	H	H		270
20b	diethyl	N-Et-5-pyrazolyl	H	4-F	31
23a	diethyl	N-Et-5-pyrazolyl	CF3	H		81
23b	diethyl	N-Me-5-pyrazolyl	CHF2	H		12
25	CD3CD2	N-Me-5-pyrazolyl	CHF2	H		16
1						25

^aIC₅₀ values represent average of three independent determinations.