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. 2023 Oct 20;66(21):14597–14608. doi: 10.1021/acs.jmedchem.3c01088

Table 3. PDE Selectivitya.

cpd PDE3A PDE4D3 PDE5A PDE6C PDE10A
14b 0 1.1 9.7 13.5 13.8
14c 0.8 6 36 20 18
18a 3 8 61 30 2
18d 0 0 48 12 5
23b 2 8 20 7 8
a

% inhibition at 500 nM, average of three independent determinations.