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. 2023 Oct 20;66(21):14597–14608. doi: 10.1021/acs.jmedchem.3c01088

Table 5. PDE11A4 Inhibitors 1, 14b and 23b Cell-Based Efficacya.

cpd EC50 (μM) cAMP EC50 (μM) cGMP
1 11 22
14b 4.7 22
23b 2.5 2.1
a

EC50 values represent the average of four independent replicates per treatment group. See the Experimental Section for statistical analysis.