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Nanoparticles for endosomal targeting of GPCRs involved in pain
| Nanoparticle | Diameter | ζ Potential (mV) | Drug | GPCR target |
|---|---|---|---|---|
| DIPMA-AP77 | 40.4 ± 5.1 | −0.2 ± 1.6 | Aprepitant | NK1R |
| DIPMA-MK320765 | 30.7 ± 1.3 | −1.3 ± 1.6 | MK3207 | CLR/RAMP1 |
| VBA-AP78 | 14.5 ± 1.9 | −5.8 ± 1.0 | Aprepitant -NH2 | NK1R |
| Benzo-AP78 | 21.1 ± 2.6 | −2.1 ± 0.3 | Aprepitant- NH2 | NK1R |
| DADLE-LipoMSN-DADLE74 | 206.5 ± 3.3 | 29.9 ± 3.07 | DADLE | DOR |
