Table 4. Rat PK^a on Analogs Meeting In Vitro Criteria.

	Cmaxb (μM)	%F	Cl mL min–1 kg–1	Vd L/kg	frac. abs.c
1	0.32	20%	6.9	0.95	22%
14b	1.4	100%	11	3.9	100%
14c	1.6	94%	7.0	1.3	100%
15a	0.57	35%	10	1.6	41%

^aiv 1 mpk (n = 3), po 4 mpk in 0.5% methylcellulose (n = 3).

^bpo dosing.

^cFraction absorbed estimated from bioavailability (%F), Cl, and hepatic blood liver flow (Q_h) = 70 mL min^–1 kg^–1.¹³