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. 2023 Nov 13;23:1101. doi: 10.1186/s12885-023-11552-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — TAB182 expression is downregulated in TNBC cells. A-B Kaplan‒Meier plots showing the probability of overall survival (OS) (A) and relapse-free survival (RFS) (B) in all breast cancer patients, who were stratified on the basis of the median TAB182 (224792_at) gene expression level. C-D TAB182 mRNA levels among healthy, tumor-adjacent, and tumor samples (C). TNBC samples express lower mRNA levels of TAB182 than non-TNBC samples D. Analysis was performed using the TCGA RNA-seq databases from bc-GenExMiner v4.9. The P value shown in the figure indicates a significant global difference among three groups (C) or two groups (D). For each pairwise comparison (C), tumor-adjacent vs. healthy, P < 0.0001; tumor vs. healthy, P < 0.0001; tumor vs. tumor-adjacent, P < 0.01. E Western blot analysis results revealed TAB182 protein levels in a normal breast cell line (MCF10A), non-TNBC cell lines (MCF7 and ZR-751), and TNBC cell lines (BT549 and MDA-MB-231). F RT‒qPCR was used to determine TAB182 mRNA levels in the same cell lines shown in E. mRNA levels are relative to the mRNA expression of TAB182 in MCF10A cells. The data are shown as the means with SD (n = 3)