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. 2023 Nov 13;23:1101. doi: 10.1186/s12885-023-11552-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — TAB182 regulated global gene expression in TNBC cells. A The pie chart presents the numbers of TAB182 KD-regulated genes (|Fold change|> 1.5, P < 0.05). B DAVID functional annotation shows the top 10 significant gene ontology biological processes (GO BP) for genes that were highly upregulated (upper) and downregulated (down) after TAB182 knockdown in MDA-MB-231 cells. P < 0.05. C Heatmaps showing the expression of TAB182 deletion-regulated genes enriched in three BP terms, including cell migration, cell proliferation, and DNA repair. The data are presented as transformed FPKM values of shTAB182 vs. shNC experiments. D A RT‒qPCR analysis confirmed the changes in gene expression identified by RNA-seq assay after TAB182 deletion. The data are shown as the means with SD relative to the control (shNC) from three independent experiments. ^* P < 0.05, ^*** P < 0.001 by Student’s t test. E GO analysis of cell component (CC) and molecular function (MF) of the genes upregulated and downregulated after TAB182 deletion, respectively. F KEGG pathway analysis [33] revealed the signaling pathways significant enriched by TAB182 KD-regulated genes in MDA-MB-231 cells