Table 3.

Factors associated with change in coronary artery z-score over follow-up

Variable	Hazard ratio (95% CI)	P value
Early∗ treatment (ref: single IVIG only)
IVIG + steroids (n = 21)	−0.4 (−4.6 to 3.8)	0.84
IVIG + infliximab (n = 27)	2.62 (−4.0 to 9.3)	0.44
Multiple IVIG (n = 132)	−0.8 (−3.5 to 1.8)	0.53
Multiple IVIG + infliximab (n = 9)	1.3 (−5.9 to 8.5)	0.73
Multiple IVIG + steroids (n = 39)	−1.1 (−4.8 to 2.6)	0.57
Multiple IVIG + infliximab + steroids (n = 3)	2.8 (−6.8 to 12.3)	0.93
Late/rescue treatment (ref: single IVIG only)
IVIG + steroids (n = 21)	4.6 (0.5 to 8.7)	0.03
IVIG + infliximab (n = 27)	−1.6 (−8.0 to 4.9)	0.64
Multiple IVIG (n = 100)	1.2 (−1.5 to 3.9)	0.39
Multiple IVIG + infliximab (n = 17)	3.5 (−2.2 to 9.2)	0.23
Multiple IVIG + steroids (n = 75)	5.4 (2.2 to 8.5)	0.57
Multiple IVIG + infliximab + steroids (n = 44)	6.4 (2.75 to 10.1)	0.55
Age at diagnosis (y)	0.90 (−0.2 to 2.0)	0.93
Maximum CAA z-score at first echo (per unit increase)	−0.2 (−0.3 to 0.1)	<0.001
Days of fever before IVIG	0.3 (0.1 to 0.4)	<0.001
Days of fever after IVIG	0.2 (0.1 to 0.4)	0.002
Bilateral CAA at diagnosis (ref: unilateral CAA)	3.4 (1.7 to 5.1)	<0.001

CAA, coronary artery aneurysms; IVIG, intravenous immunoglobulin.

^∗Treatments were considered early adjunctive therapy if they were given within 3 days of initial IVIG.