Table 5.
Factors associated with major adverse cardiac events in Cox multivariable regression
| Variable | Hazard ratio (CI) | P value |
|---|---|---|
| Early adjunctive treatment (ref: single IVIG only) | ||
| IVIG + steroids | 1.0 (0.3-3.0) | 0.93 |
| IVIG + infliximab | 3.3 (0.2-49.0) | 0.38 |
| Multiple IVIG only | 0.5 (0.2-1.5) | 0.21 |
| Multiple IVIG + infliximab | 3.2 (0.5-20.7) | 0.23 |
| Multiple IVIG + steroids | 0.2 (0.04-1.2) | 0.07 |
| Multiple IVIG + infliximab + steroids | No events | – |
| Late/rescue treatment (ref: single IVIG only) | ||
| IVIG + steroids | 2.9 (0.9-9.5) | 0.07 |
| IVIG + infliximab | 0.5 (0.02-12.0) | 0.68 |
| Multiple IVIG only | 1.4 (0.4-4.2) | 0.58 |
| Multiple IVIG + infliximab | 1.6 (0.2-13.6) | 0.66 |
| Multiple IVIG + steroids | 2.8 (0.9-8.8) | 0.08 |
| Multiple IVIG + infliximab + steroids | 2.6 (0.7-9.6) | 0.15 |
| Age at diagnosis (y) | 1.03 (0.95-1.12) | 0.53 |
| Maximum CAA z-score at first echo (per unit increase) | 1.04 (1.00-1.13) | <0.001 |
| Days of fever before IVIG | 1.04 (1.00-1.08) | 0.03 |
| Days of fever after IVIG | 0.98 (0.95-1.02) | 0.05 |
| Bilateral CAA at diagnosis (ref: unilateral CAA) | 6.90 (0.93-51.26) | 0.06 |
CAA, coronary artery aneurysm; CI, confidence interval; IVIG, intravenous immunoglobulin.