Table 1.
cGAS and STING antagonists.
| cGAS and STING antagonists | References | |
|---|---|---|
| cGAS Catalytic site inhibitors | PF-06928125 | (56) |
| RU.521 | (57) | |
| G150 | (58) | |
| Compound S3 | (59) | |
| Disrupt DNA binding | X6 | (60) |
| Suramin | (61) | |
| A151 | (62) | |
| Hydroxychloroquine | (63) | |
| Quinacrine | (63) | |
| Targeting the CDN-binding site | Tetrahydroisoquinolines (compound 18) | (64) |
| Astin C | (65) | |
| SN-011 | (66) | |
| Targeting STING palmitoylation sites | Nitrofurans (C-176 and C-178) |
(67) |
| Indole ureas (H-151) | (67) | |
| Nitro fatty acids (NO2-FA) | (68) | |
| Acrylamides (BPK-21, BPK-25) |
(69) | |
| unknown mechanism | CU-76 | (70) |
| compound 13 | (71) | |
| SP23 | (72) | |
| VS-X4 | (73) | |
Overview of cGAS and STING agonists is presented in Supplementary .